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M9630677.TXT
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1996-02-27
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Document 0677
DOCN M9630677
TI Management of blood donors whose donations are repeatedly falsely
positive by the HIV antibody screening test.
DT 9603
AU Atrah HI; Parry JV; Gough D; Tosswill J; Ala FA; West Midlands Regional
Blood Transfusion Service, Edgbaston,; Birmingham.
SO J Clin Pathol. 1995 Sep;48(9):865-7. Unique Identifier : AIDSLINE
MED/96096278
AB Since 1985, over 1,800,000 donations have been screened by the West
Midlands Regional Blood Transfusion Service for antibody to HIV. Twelve
regular donors gave three or more donations that were alternatingly
positive and negative in the screening test, but not confirmed to be HIV
positive by supplementary testing. Extensive investigation of six of
these donors, including the polymerase chain reaction (PCR), failed to
confirm HIV infection. The donors were reassured but, nevertheless,
retired to comply with the guidelines of the National Blood Transfusion
Service. These findings indicate that, for UK donors, ambiguous
serological findings are unlikely to reflect HIV infection. On the rare
occasions where serological results are particularly ambiguous, PCR
testing of donors' blood may be helpful.
DE Adult *AIDS Serodiagnosis *Blood Donors False Positive Reactions
Female Human HIV Seropositivity/*DIAGNOSIS Male *Mass Screening
Middle Age Polymerase Chain Reaction JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).